Hairspray is a musical with music by Marc Shaiman, lyrics by Scott Wittman and Shaiman and a book by Mark O'Donnell and Thomas Meehan, based on the 1988 John Waters film Hairspray. The songs include 1960s-style dance music and "downtown" rhythm and blues. In 1962 Baltimore, Maryland, plump teenager Tracy Turnblad's dream is to dance on The Corny Collins Show, a local TV dance program based on the real-life Buddy Deane Show.When Tracy wins a role on the show, she becomes a celebrity overnight. She then launches a campaign to integrate the show. Hairspray is a social commentary on the injustices of parts of American society in the 1960s.

The musical's original Broadway production opened on August 15, 2002 and won eight Tony Awards out of thirteen nominations. It ran for over 2,500 performances and closed on January 4, 2009. Hairspray has also had U.S. national tours, a London West End production and numerous foreign productions and was adapted for a 2007 musical film. The London production was nominated for a record-setting eleven Laurence Olivier Awards, winning for Best New Musical and in three other categories.

According to interviews included as an extra feature on the 2007 film's DVD release, theatre producer Margo Lion first conceived of Hairspray as a stage musical in 1998 after seeing a television broadcast of the original film. She contacted John Waters, who gave her his blessing, then acquired the rights from New Line Cinema. Lion contacted Marc Shaiman, who expressed interest in the project only if his partner Scott Wittman could be included, and Lion agreed. The two submitted three songs – one of which, "Good Morning Baltimore," eventually became the show's opening number. Based on their initial work, Lion was confident that she had hired the right team.

Lion contacted Rob Marshall about directing the musical. At the time he was involved in negotiations to direct the screen adaptation of Chicago, but he agreed to become involved in the early development stages of Hairspray with the stipulation he would drop out if assigned the film. Marshall remembered Marissa Jaret Winokur from her brief appearance in the film American Beauty and arranged a meeting with Shaiman and Wittman. The two immediately felt she was right for the role of Tracy Turnblad but were hesitant to commit without seeing any other auditions. They hired Winokur to work with them on the project with the understanding she might be replaced later. One year later, Winokur was diagnosed with cervical cancer. Certain she would lose the role if the creative team learned about her condition, she underwent chemotherapy and a hysterectomy without telling anyone but her immediate family. The treatment and surgery were successful, and Winokur returned to the project. Meanwhile, Marshall had started work on Chicago, and Jack O'Brien and Jerry Mitchell were hired by Lion to direct and choreograph, respectively. Winokur was one of the first to audition for the role of Tracy Turnblad and spent two years preparing with voice and dance lessons. Tracy's mother had been portrayed by Divine in the original film, and Shaiman liked the idea of maintaining the tradition of casting a male as Edna Turnblad. Harvey Fierstein auditioned for the role with a "half hour vocal audition" of "an entire concert". He thought they were "pacifying" him, but he was told "they don't want anyone but you".

According to Shaiman, one song, "I Know Where I've Been", became controversial during the genesis of the score:

“This was... inspired by a scene late in the [1988] movie that takes place on the black side of town. It never dawned on us that a torrent of protest would follow us from almost everyone involved with the show. ‘It’s too sad.... It’s too preachy.... It doesn’t belong.... Tracy should sing the eleven o’clock number.’ We simply didn’t want our show to be yet another show-biz version of a civil rights story where the black characters are just background. And what could be more Tracy Turnblad-like than to give the ‘eleven o’clock number’ to the black family at the heart of the struggle? Luckily... the audiences embraced this moment, which enriches the happy ending to follow, and it is our proudest achievement of the entire experience of writing Hairspray.

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