The Stanford St. Jude Championship is a regular golf tournament on the PGA Tour. It has been played annually in Memphis, Tennessee on the course at the Tournament Players Club at Southwind since 1989. In 2007, The Stanford Financial Group took over the tournament's title sponsor, and it was renamed Stanford St. Jude Championship.

In 2008, the total purse was $6,000,000, with $1,080,000 going to the winner.

The tournament was founded in 1958 as the Memphis Open and was played annually at Colonial Country Club first in Memphis, then in Cordova, Tennessee until 1989. In 1969, actor Danny Thomas agreed to lend his name to the tournament in exchange for his St. Jude Children's Research Hospital becoming the tournament's charity. Accordingly, the tournament changed its name the next year to the Danny Thomas Memphis Classic. In 1977, President Gerald Ford, who had just left office, hit a hole-in-one at the tournament's Celebrity Pro-Am. The same year, Al Geiberger shot a record 59 (13-under-par) round. In 1989, the event moved from Colonial Country Club to its present location at the TPC at Southwind in Memphis.

The winner of the tournament each year is given a blue and white seersucker jacket.